Hybrid chemotherapy consisting of cyclophosphamide, vincristine, procarbazine, prednisone, doxorubicin, bleomycin, and vinblastine (C-MOPP/ABV) as first-line treatment for patients with advanced Hodgkin disease.In this case, vaginal obliteration was an early sign of tumor recurrence, although menopause may have contributed to the vaginal obliteration. CONCLUSION: Physicians should be greatly concerned about the frequency and severity of treatment-associated acute and long-term complications, such as gonadal toxicity. Pathology showed widespread lymphoma throughout the perineal area, including the neovagina, deep pelvic cavity and the entire abdominal cavity. The patient underwent intensive medical treatment and surgical intervention, but died 2 months later. Imaging studies (computed tomography) and laboratory evaluations indicating a suspicious pelvic abscess with leukocytosis (16,800/mm(3)) and elevated serum C-reactive protein (18.4 mg/L) levels. CASE REPORT: A 42-year-old married woman with a history of Mayer-Rokitansky-Küster-Hauser syndrome, an established neovagina, and complete clinical remission of cutaneous T-cell lymphoma (stage T4) treated with bleomycin, cyclophosphamide, doxorubicin, vincristine and prednisolone had suffered from abdominal pain. We report a case that emphasizes a clinically rare complication, the complete obliteration of the vagina. N2 - OBJECTIVE: Although ovarian failure commonly occurs following chemotherapy, the relation between menopause or related sexual activity in this failure is often overlooked. JF - Taiwanese journal of obstetrics & gynecology T1 - Vaginal obliteration in a woman with a history of cutaneous T-cell lymphoma: the results of combined chemotherapy-induced gonadal toxicity and lymphoma relapse.
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